Indianapolis is the capital and largest city of the U.S. state of Indiana and the seat of Marion County. It is in the East North Central region of the Midwestern United States. With an estimated population of 855,164 in 2016, Indianapolis is the third most populous city in the Midwest and 15th most populous in the U.S. The city is the economic and cultural center of the Indianapolis metropolitan area, home to 2 million people, the 34th most populous metropolitan statistical area in the U.S. Its combined statistical area ranks 27th, with 2.38 million inhabitants. Indianapolis covers 368 square miles (950 km2), making it the 16th largest city by land area in the U.S.